Husband-and-wife PhD students Eric Minikel and Sonia Vallabh have switched careers to pursue research into a rare genetic disease that killed Ms Vallabh’s mother and could kill her.

Insurance executive Mark Bertolini once quit his job to manage his cancer-stricken son’s care in person, learning lessons he later used to run one of the largest US health insurers. “Time is short,” says the chief executive of Aetna, who wears a black skull-shaped ring as a memento mori.

Here are two examples of people whose work is driven by meaning and purpose. A cynic might say they are extreme exceptions to the rule that most staff slouch into the office without much sense of what they give to their job, other than too many hours each day, and what they want from it, other than a prompt finish and a regular pay cheque.